Most drugs for ophthalmic use like pilocarpine, epinephrine, general anesthetics, atropine, and so on are susceptible bases which are commonly formulated at acidic pH to improve stability. But due to their fantastically ionized form, ocular diffusion is poor. This coupled with tear drainage, in addition, reduces the rate and extent of absorption. Moreover, if the drug has a quick half-life, the issues emerge as extra complicated. Frequent dosing of massive doses of such drugs turns into necessary to acquire the therapeutic objective which regularly effects in corresponding amplification in local and systemic side effects. So, look up on Novel ophthalmic drug delivery systems is in a process to overcome all these negative aspects of traditional ophthalmic dosage forms.
- Mucoadhesive Formulations